Drugs for Intestinal Helminths of Dogs Approved in the US and UK

Drug or Drug Combination	Dosage (mg/kg), Frequency	Route of Administration	Helminths Active Against^a
*Approved in both US and UK*
Milbemycin oxime + lufenuron	0.5/10, monthly	PO	Toxocara canis, Ancylostoma caninum, Trichuris vulpis
Milbemycin oxime + praziquantel	0.5/5, monthly	PO	T canis, Toxascaris leonina, A caninum, T vulpis, Dipylidium caninum, Taenia spp,^fEchinococcus spp^g
Moxidectin + imidacloprid	2.5/10, monthly	Topical	T canis, T leonina, A caninum, Uncinaria stenocephala, T vulpis
Approved only in US
Fenbendazole	50, daily for 3 days	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis, Taenia pisiformis
Epsiprantel	5.5, once	PO	D caninum, T pisiformis
Milbemycin oxime	0.5, monthly	PO	T canis, T leonina, A caninum, T vulpis
Milbemycin oxime + lufenuron	0.5/10, monthly	PO	T leonina
Milbemycin oxime + lufenuron + praziquantel	0.5/10/5, monthly	PO	T canis, T leonina, A caninum, T vulpis, D caninum, T pisiformis, Echinococcus granulosus, Echinococcus multilocularis
Milbemycin oxime + spinosad	0.5/30, monthly	PO	T canis, T leonina, A caninum, T vulpis
Moxidectin	6-month product: 0.17, once 12-month product: 0.5, once	SC	A caninum, U stenocephala
Moxidectin	2.5, monthly	Topical	T canis, T leonina, A caninum, U stenocephala, T vulpis
Piperazine (various salts)	48–66 (max 150 mg/puppy), once; repeat in 10 days and then monthly to prevent reinfection^b	PO	T canis, T leonina
Praziquantel	5–12.5 (max 170 mg/puppy or dog), once	PO	D caninum, T pisiformis, E granulosus,^cE multilocularis^c
Praziquantel	5–11.4 (max 170 mg/puppy or dog), once	SC, IM	D caninum, T pisiformis, E granulosus, E multilocularis
Pyrantel pamoate	5 (10 for dogs ≤ 2.3 kg), once; monthly to prevent reinfection in adults	PO	T canis, T leonina, A caninum, U stenocephala
Ivermectin + pyrantel pamoate	0.006/5, monthly	PO	T canis, T leonina, A caninum, Ancylostoma braziliense, U stenocephala
Praziquantel + pyrantel pamoate	5/5, once	PO	T canis, T leonina, A caninum, A braziliense, U stenocephala, D caninum, T pisiformis
Praziquantel + pyrantel pamoate + febantel	7/7/35, once	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis, D caninum, T pisiformis, E granulosus,^cE multilocularis^c
Praziquantel + pyrantel pamoate + ivermectin	5/5/0.006, monthly	PO	T canis, T leonina, A caninum, A braziliense, U stenocephala, D caninum, T pisiformis
*Approved only in UK*
Fenbendazole	100 once, or 50 daily for 3 days^d	PO	T canis, T leonina, Ancylostoma spp, Uncinaria spp, Trichuris spp, Taenia spp, Oslerus osleri^d
Praziquantel	5, once	PO	D caninum, T pisiformis, Taenia multiceps, Taenia hydatigena, Taenia ovis, E granulosus, E multilocularis
Selamectin	6, monthly	Topical	T canis
Febantel + pyrantel embonate^e	15/14.4, daily for 3 days	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis
Milbemycin + afoxolaner	0.50–1.07/2.50–5.36, monthly	PO	T canis, T leonina, A caninum, A braziliense, Ancylostoma ceylanicum, T vulpis, Angiostrongylus vasorum, Thelazia callipaeda
Milbemycin oxime + praziquantel	0.5/5, monthly	PO	Mesocestoides spp, Crenosoma vulpis, A vasorum, T callipaeda
Moxidectin + imidacloprid	2.5/10, monthly	Topical	Spirocera lupi, A vasorum, C vulpis, Eucoleus boehmi,^cT callipaeda^c
Praziquantel + pyrantel embonate + febantel	5/14.4/15, daily for 3 days	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis,^cD caninum,^cTaenia spp^c (T hydatigena,^cT pisiformis^c), Echinococcus spp^c (E granulosus,^cE multilocularis^c)
^a Many of these drugs are also approved for use against other types of parasites (eg, fleas, heartworms) not listed here.
^b Repeat after 10–20 days.
^c Only some products.
^d 7 days for O osleri.
^e This formulation is not commercially available in the UK.
^fT pisiformis in the US.
^gE multilocularis and E granulosus in the US.

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