Dosages of Antistaphylococcal Antimicrobials

Cephalosporins

Cephalexin

20–30 mg/kg, PO, q 12 h for 21–42 d (treat for 5–7 d beyond resolution of clinical disease or preferably negative culture result)

Cefadroxil

Dogs: 20 mg/kg, PO, q 12 h for 3–30 d

Cats: 20 mg/kg, PO, q 24 h for a minimum of 3 weeks

Cefaclor

10–25 mg/kg, PO, q 12 h for 3–30 d

Cefovecin

8 mg/kg, SC, q 14 d, repeated as needed if response to therapy is not complete (maximum treatment should not exceed 2 injections)^a

Cefpodoxime

5–10 mg/kg, PO, q 24 h for 5–7 d or for 2–3 days beyond the cessation of clinical signs (recommended maximum interval is to 28 days)

Penicillins

Amoxicillin-clavulanate

13.75 mg/kg, PO, q 12 h for 5–7 d

Oxacillin

22 mg/kg, PO, q 8 h for 14–21 d

Fluoroquinolones

Enrofloxacin

5 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution

Marbofloxacin

2 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution

Orbifloxacin

2.5 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution

Difloxacin

5 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution

Pradofloxacin

3 mg/kg, PO, q 24 h for 7–14 days beyond clinical resolution

Sulfonamides

Trimethoprim-sulfadiazine

15–30 mg/kg, PO, q 12 h for 14–42 d

Trimethoprim-sulfamethoxazole

15–30 mg/kg, PO, q 12 h for 14–42 d

Macrolides

Erythromycin

15–30 mg/kg, PO, q 8 h for 7–10 d

Clindamycin

Dogs: 10–20 mg/kg, PO, q 12 h for 7–28 d

Cats: 12.5–25 mg/kg, PO, q 12 h for 7–28 d

Lincomycin

10–20 mg/kg, PO, q 12 h for 12–42 d

Azithromycin

10 mg/kg, PO, q 24 h for 5–7 d

Others

Chloramphenicol

50 mg/kg, PO, q 8 h for 7–14 d

Rifampin

5–10 mg/kg, PO, q 12–24 h (duration as needed)