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Drugs Used to Treat Behavior Problems in Cats

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Drug	Uses	Comments
Tricyclic antidepressants
Amitriptyline	Anxiety, aggression, compulsive disorders, inappropriate urination, feline lower urinary tract disease, neuropathic pain	Has analgesic, antidepressant, and antihistamine effects
Clomipramine	Anxiety, aggression, compulsive disorders, urine marking
Selective serotonin reuptake inhibitors
Fluoxetine	Anxiety, aggression, compulsive disorders, urine marking	May take 3 to 4 weeks before affecting behavior
Paroxetine	Anxiety, aggression, compulsive disorders, urine marking
Sertraline	Anxiety, aggression, compulsive disorders
Azapirones
Buspirone	Anxiety, urine marking
Benzodiazepines
Alprazolam	Anxiety	Longer acting than other drugs of this class
Clonazepam	Anxiety	Also used to control seizures
Diazepam	Anxiety, urine marking	May cause physical dependence; watch for signs of decreased appetite or depression because this drug has been reported to cause severe liver damage in rare cases
Monoamine oxidase inhibitor
Selegiline	Cognitive dysfunction (senility)	Approved for use in dogs, but also used as an extra-label medication in cats