Medical Causes of Behavioral Signs

Medical Condition

Behavioral Signs

Illness or disease

Altered personality, lethargy, listlessness, withdrawal, anorexia, decrease in grooming, altered social relationships, altered response to stimuli

Neurological

Central (affecting forebrain, limbic/temporal, and hypothalamic), rapid-eye movement sleep disorders

Altered awareness and response to stimuli, loss of learned behaviors, house soiling, disorientation, confusion, altered activity levels, temporal disorientation, vocalization, change in temperament (fear, anxiety, aggression), altered appetite, altered sleep cycles, interrupted sleep (aggression/waking/activity)

Peripheral (neuropathy)

Self-mutilation, irritability, aggression, circling, hyperesthesia

Focal seizures/temporal lobe seizures

Repetitive behaviors, self-trauma, chomping, staring, altered temperament (eg, intermittent states of fear or aggression), tremors, shaking, interrupted sleep

Sensory dysfunction

Altered response to stimuli, confusion, disorientation, altered sleep cycles, irritability, aggression, vocalization, house soiling

Metabolic/Endocrine

Feline hyperthyroidism

Irritability, aggression, urine marking, increased activity, night waking

Canine hypothyroidism

Lethargy, decreased response to stimuli, irritability, aggression

Hyperadrenocorticism

Panting, night waking, house soiling, irritability, polyphagia, anxiety

Diabetes/hyperglycemia

House soiling, night waking

Functional ovarian and testicular tumors

Androgen-induced behaviors: males—aggression, roaming, marking, sexual attraction, mounting; females—nesting or possessive aggression of objects

Hepatic encephalopathy; renal encephalopathy

Clinical signs associated with affected organ, anxiety, irritability, aggression, altered sleep, house soiling, mental dullness, decreased activity, restlessness, increased sleep, confusion

Anemia or electrolyte imbalances

Pica

Pain

Altered response to stimuli, decreased activity, restlessness/inability to settle, vocalization, house soiling, aggression, irritability, self-trauma, waking at night

GI

Licking, polyphagia, pica, coprophagia, house soiling (fecal), wind sucking, tongue rolling, unsettled sleep, restlessness

Urogenital

House soiling (urine), polydipsia, waking at night

Dermatological

Psychogenic alopecia (cats), acral lick dermatitis (dogs), nail biting, hyperesthesia, other self-trauma