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Proteins Synthesized, Activated, Regulated, or Cleared by the Liver Impacting Coagulation Status

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Category	Relevant Proteins
Procoagulants	Fibrinogen, prothrombin, factor V, Factor VII, Factor VIII (vascular origin), Factor IX, Factor X, Factor XI, Factor XII, Factor XIII
Anticoagulants	Antithrombin, Protein C, Protein S, Tissue factor pathway inhibitor
Profibrinolytics	Factor XIIa, Plasmin (derived from circulating plasminogen)
Antifibrinolytics	Plasminogen activator inhibitor-1, Alpha-antiplasmin, Thrombin-activatable fibrinolysis inhibitor
Regulators of platelet production	Thrombopoietin: hormone synthesized in liver; stimulates thrombopoiesis