WHO Clinical Staging System for Lymphoma in Domestic Animals

Stage*

Description

I

Involvement limited to a single node or lymphoid tissue in a single organ (excluding bone marrow)

II

Involvement of many lymph nodes in a regional area (with or without involvement of the tonsils)

III

Generalized lymph node involvement

IV

Stage I, II, or III with liver or spleen involvement

V

Stage I, II, III, or IV with manifestation in the blood and involvement of bone marrow or other organ systems

* Each stage is further classified into substages based on the presence of systemic signs: substage a = absence of systemic signs; substage b = presence of systemic signs (fever, > 10% weight loss, hypercalcemia)

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