Spiroindoles

Derquantel has been approved as a combination anthelmintic product with abamectin. By adding abamectin to derquantel, the spectrum of parasite species against which this combination exhibits ≥95% efficacy is significantly increased. At the dose rate selected for the combination product, derquantel has excellent anthelmintic activity against the adult and L4 stages of Trichostrongylus spp and Nematodirus spp and the adult stage of Haemonchus spp, and has demonstrated variable efficacy against Teladorsagia circumcincta and the L4 stages of H contortus.